代谢组学在新生儿临床中的应用

Application of metabolomics in neonatal clinical practice

摘要:

代谢组学是后基因组时代新兴的热门学科，国内外在人体的健康评估、生长发育、疾病诊断及疗效评估等方面均有大量研究。新生儿期作为生命的特殊时期，其细胞迅速更新、大量能量及物质被消耗、代谢途径的更改，均会对代谢物水平产生影响。然而新生儿的代谢水平和代谢轮廓目前尚无参考标准。该文综述了目前国内外新生儿生长发育和常见疾病的代谢研究状况及其临床应用现状，从代谢角度重新认识新生儿生长发育过程、常见病和多发病，将会为新生儿营养指导和评估、疾病治疗方案的选择、新的药物研究提供思路。

Abstract:

Metabolomics is an emerging and popular subject in the post-genome era, and a large number of studies have been noted on the application of metabolomics in health evaluation, growth and development evaluation, disease diagnosis, and therapeutic efficacy evaluation. As a special period of life, the neonatal period is characterized by rapid cell renewing, consumption of a lot of energy and materials, and changes in metabolic pathways, all of which affect the level of metabolites. However, there is still no reference standard for metabolic level and profile in neonates. This article reviews the current status of metabolic research on neonatal growth and development and common diseases and related clinical application of metabolomics, so as to provide new ideas for nutrition guidance and evaluation, selection of therapeutic regimens, and new drug research in neonates.