从SARS、MERS到COVID-19看母婴垂直传播的可能性

Possibility of mother-to-child vertical transmission of coronavirus infection from the perspectives of severe acute respiratory syndrome, Middle East respiratory syndrome, and coronavirus disease 2019

摘要:

评估孕妇感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）对新生儿2019冠状病毒病发病的潜在影响，探讨SARS-CoV-2母婴垂直传播的可能性。该文根据目前已经发表的相关文献和官方网站信息，分析总结了SARS、MERS期间及COVID-19暴发后报道的孕妇感染相关病毒后所分娩的新生儿病例的临床表现和实验室检查。从目前证据尚不足以得出COVID-19母婴垂直传播的结论，需累积更多的病例进一步评估。

Abstract:

This article evaluates the potential influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnant women on the development of coronavirus disease 2019 in neonates and discusses the possibility of mother-to-child vertical transmission of SARS-CoV-2. With reference to related articles published up to now and the information on official websites, a retrospective review was performed for the clinical manifestations and laboratory examination results of the neonates born to the mothers with infection during pregnancy during the epidemics of severe acute respiratory syndrome and Middle East respiratory syndrome and after the outbreak of SARS-CoV-2 infection since December 2019. Based on the limited data, there is no conclusive evidence for mother-to-child vertical transmission of coronavirus disease 2019, and more cases need to be collected for further evaluation.