印度尼西亚儿童牛奶摄入与乳糖吸收不良之间的关系

Association between milk consumption and lactose malabsorption in Indonesian children

摘要:

目的 探讨3~12岁印度尼西亚儿童牛奶摄入与乳糖吸收不良之间的关系。 方法 该研究为横断面研究。研究对象为在印度尼西亚雅加达中部随机选取的营养状况良好的174名3~12岁健康儿童，包括72名3~5岁儿童和102名6~12岁儿童。 结果 3~5岁儿童乳糖吸收不良患病率为20.8%（15/72），6~12岁儿童乳糖吸收不良患病率为35.3%（36/102）。牛奶或乳制品摄入与乳糖吸收不良之间无显著关联性（P>0.05）。在氢呼气试验中，51例乳糖吸收不良儿童主要表现为腹泻（62%）、腹痛（52%）和恶心（5%）。 结论 3~12岁印度尼西亚儿童牛奶摄入和乳糖吸收不良无关联，这提示遗传易感性可能比乳糖摄入的适应机制更重要。

Abstract:

Objective To study the association between milk consumption and lactose malabsorption in Indonesian children aged 3-12 years. Methods This cross sectional study was conducted in randomly selected presumed healthy children with good nutritional status aged 3-12 years in Central Jakarta, Indonesia (n=174), including 72 children aged 3-5 years and 102 children aged 6-12 years. Results The prevalence of lactose malabsorption in children aged 3-5 years and children aged 6-12 years was 20.8% (15/72) and 35.3% (36/102), respectively. There was no association between milk or milk product consumption and lactose malabsorption (P>0.05). In the 51 children with lactose malabsorption, the predominant clinical symptoms were diarrhea (62%), abdominal pain (52%), and nausea (5%) during the hydrogen breath test. Conclusions There is no association between milk consumption and lactose malabsorption in Indonesian children aged 3-12 years, suggesting that genetic predisposition may be more important than adaptive mechanisms to lactose consumption.