儿童吉兰-巴雷综合征需要辅助呼吸的危险因素分析

Risk factors associated with the need for mechanical ventilation in children with Guillain-Barré syndrome

摘要:

目的 研究儿童吉兰-巴雷综合征（Guillain-Barré syndrome，GBS）需要辅助呼吸的危险因素。 方法 回顾性收集107例GBS患儿的临床资料。根据是否需要辅助呼吸，分为需要辅助呼吸组（n=16）和不需要辅助呼吸组（n=91）。比较两组患儿的临床资料，采用多因素logistic回归分析法分析GBS患儿需要辅助呼吸的危险因素。 结果 107例GBS患儿中，16例患儿需要辅助呼吸，发生率为15.0%。需要辅助呼吸组面肌和/或延髓肌无力比例高于不需要辅助呼吸组，起病到病情高峰期天数短于不需要辅助呼吸组，首次就诊休斯功能分级量表得分高于不需要辅助呼吸组（均P<0.05）。面肌和/或延髓肌无力、起病到病情高峰期天数短是GBS患儿需要辅助呼吸的危险因素（分别OR=5.053、1.239，P<0.05）。 结论 面肌和/或延髓肌无力和起病到病情高峰期天数的缩短可能增加GBS需要辅助呼吸的风险。 引用格式:

Abstract:

Objective To study the risk factors associated with the need for mechanical ventilation in children with Guillain-Barré syndrome (GBS). Methods The medical data of 107 children with GBS were retrospectively reviewed. According to whether mechanical ventilation was required, the children were divided into a mechanical ventilation group with 16 children and a non-mechanical ventilation group with 91 children. The risk factors associated with the need for mechanical ventilation in children with GBS were identified by a multivariate logistic regression analysis. Results Among the 107 children, 16 (15.0%) required mechanical ventilation. Compared with the non-mechanical ventilation group, the mechanical ventilation group had a significantly higher proportion of children with facial and/or bulbar muscle weakness, a significantly shorter duration from the onset to the peak of the disease, and a significantly higher Hughes Functional Grading Scale score at the first visit (P<0.05). Facial and/or bulbar muscle weakness and short duration from the onset to the peak of the disease were risk factors associated with the need for mechanical ventilation in children with GBS (OR=5.053 and 1.239 respectively, P<0.05). Conclusions Facial and/or bulbar muscle weakness and short duration from the onset to the peak of the disease may increase the risk of mechanical ventilation in children with GBS. Citation: