过敏性紫癜患儿血清降解单糖水平的变化及意义

Serum levels of degraded monosaccharides in children with Henoch-Sch?nlein purpura

摘要:

目的 分析过敏性紫癜（Henoch-Sch?nlein purpura，HSP）患儿血清降解单糖的水平变化特点，并探讨其临床意义。 方法 前瞻性选取2019年9月至2022年1月诊断为HSP的132例患儿为研究对象，另选取健康儿童132例为对照组，利用高效液相色谱技术分析2组血清降解单糖的含量。通过受试者工作特征曲线分析降解单糖的诊断效果。 结果 HSP患儿血清降解甘露糖、氨基葡萄糖、氨基半乳糖和半乳糖浓度均高于对照组（P<0.001），4种降解单糖的曲线下面积分别为0.919、0.913、0.832、0.932（P<0.05），对HSP具有诊断价值。 结论 HSP患儿血清中降解甘露糖、氨基葡萄糖、氨基半乳糖和半乳糖的含量高，其水平对HSP的诊断可能具有重要价值。

Abstract:

Objective To examine the serum levels of degraded monosaccharides in children with Henoch-Sch?nlein purpura (HSP) and to study the clinical significance of degraded monosaccharides in HSP. Methods A prospective analysis was performed on 132 children who were diagnosed with HSP from September 2019 to January 2022, and 132 healthy children were enrolled as the control group. High-performance liquid chromatography was used to determine the content of degraded monosaccharides in serum in both groups. The receiver operating characteristic (ROC) curve was used to evaluate the efficiency of degraded monosaccharides for the diagnosis of HSP. Results Compared with the control group, the HSP group had significantly higher serum levels of mannose, glucosamine, aminogalactose, and galactose (P<0.001). The four degraded monosaccharides had an area under the ROC curve of 0.919, 0.913, 0.832, and 0.932 respectively for the diagnosis of HSP (P<0.05). Conclusions Children with HSP have higher serum levels of mannose, glucosamine, aminogalactose, and galactose than the healthy population. The levels of degraded monosaccharides may have an important value for the diagnosis of HSP.