STAT5与儿童急性淋巴细胞白血病关系的研究进展

Recent research on the association between signal transducer and activator of transcription 5 and childhood acute lymphoblastic leukemia

摘要:

信号转导和转录激活因子5（signal transducer and activator of transcription，STAT5）可参与细胞增殖、分化、凋亡和造血等过程，其失调与白血病等恶性肿瘤的发生发展关系密切，且影响患儿治疗效果及预后。识别STAT5有助于进行靶向治疗从而提高急性淋巴细胞白血病患儿的治疗应答率。该文就STAT5对儿童急性淋巴细胞白血病发生发展的影响、靶向治疗策略及对患儿预后的影响进行综述。

Abstract:

Signal transducer and activator of transcription 5 (STAT5) can be involved in the processes such as cell proliferation, differentiation, apoptosis, and hematopoiesis, and its dysregulation is closely associated with the development and progression of malignant tumors including leukemia and may affect the treatment outcome and prognosis of pediatric patients. Identification of STAT5 can facilitate targeted therapy to improve the response rate of children with acute lymphoblastic leukemia. This article reviews the impact of STAT5 on the development/progression, targeted therapy strategies and the prognosis of childhood acute lymphoblastic leukemia.