36株青少年幽门螺杆菌耐药分析

Antimicrobial resistance of 36 strains of Helicobacter pylori in adolescents

摘要:

目的：了解该地区青少年幽门螺杆菌(HP)常用抗菌药物的耐药性。方法：对108例青少年患者进行胃镜检查，并取胃黏膜标本1块进行HP培养分离，采用Kirby-Baner药敏纸片对培养分离到的菌株进行抗菌药物的敏感性试验。结果：108例中成功分离出HP菌株36例，对克拉霉素耐药率8.3%（3/36）、阿莫西林耐药率33.3%（12/36）、甲硝唑耐药率94.4%（34/36）、呋喃唑酮耐药率16.7%（6/36），而庆大霉素和左氧氟沙星均未检出耐药菌株。结论：该地区青少年HP对甲硝唑和阿莫西林耐药率较高，对克拉霉素和呋喃唑酮耐药率较低，而对庆大霉素和左氧氟沙星无耐药菌株。［中国当代儿科杂志，2009，11（3）：210-212］

Abstract:

OBJECTIVE: To investigate the resistance of Helicobacter pylori (H.pylori) to antimicrobial agents in adolescents. METHODS: One hundred and eight adolescents (6-18 years old) underwent a gastroscopy examination. H.pylori strains were isolated from gastric mucosa. Antimicrobial susceptibility testing was performed by means of Kirby-Baner. RESULTS: Thirty-six H.pylori strains were identified. The resistant rate of H.pylori strains to clarithromycin, fruranzolidone and amoxicillin was 8.3%, 16.7% and 33.3%, respectively. H.pylori strains showed a high resistance to metronidazole (94.4%), while no strain was resistant to gentamicin and levofloxacin. CONCLUSIONS:The H.pylori strains from the adolescents in Zhejiang showed a high resistance to metronidazole and amoxicillin but a low resistance to clarithromycin and fruranzolidone. All of H.pylori strains were susceptive to gentamicin and levofloxacin.［Chin J Contemp Pediatr, 2009, 11 (3):210-212］