NF-κB信号通路在儿童川崎病心脏损伤中的研究进展

Recent research on the nuclear factor-kappa B signaling pathway in cardiac injury in children with Kawasaki disease

摘要:

川崎病，又称为皮肤黏膜淋巴结综合征，是一种全身急性血管炎性病变，属于自身免疫性疾病。目前，该疾病发病具体机制尚不明确，可能涉及核因子κB（nuclear factor-kappa B，NF-κB）信号通路参与的免疫反应、炎症反应、血管内皮损伤等诸多因素。尤其是川崎病合并心脏损伤患儿预后不佳，研究人员希望通过探索川崎病心脏损伤的具体发病机制，为临床诊断和治疗提供新的选择，并降低其发病率。该文就NF-κB信号通路在儿童川崎病心脏损伤中的机制进展做一综述，为后续研究提供理论指导。

Abstract:

Kawasaki disease (KD), also known as mucocutaneous lymph node syndrome, is a systemic acute vasculitis belonging to autoimmune disease. Up to now, the specific pathogenesis of this disease remains unclear, and it may involve various factors such as immune response, inflammatory response, and vascular endothelial injury caused by the activation of the nuclear factor-kappa B (NF-κB) signaling pathway. In particular, children with KD and cardiac injury tend to have a poor prognosis, and researchers hope to explore the specific pathogenesis of cardiac injury in KD to provide new options for clinical diagnosis and treatment and reduce the incidence rate of this disorder. This article reviews the recent research on the role of the NF-κB signaling pathway in cardiac injury in children with KD, so as to provide a basis for future studies.