急性淋巴细胞白血病儿童认知功能损害的临床研究进展

Recent research on cognitive impairment in children with acute lymphoblastic leukemia

摘要:

急性淋巴细胞白血病（acute lymphoblastic leukemia，ALL）是儿童期最常见的恶性肿瘤性疾病。随着临床诊治水平的不断提高，获得完全缓解后长期生存的ALL儿童越来越多，其中相当部分患儿都存在认知功能损害，并对学习、就业和社交活动产生严重的不良影响。该文从ALL患儿认知功能损害的影响因素、检测技术的应用及预防与治疗对ALL患儿认知损害的临床研究进展进行综述。

Abstract:

Acute lymphoblastic leukemia (ALL) is the most common malignant neoplastic disease in children. With the continuous improvement in diagnosis and treatment, there has been an increasing number of ALL children who achieve long-term survival after complete remission; however, a considerable proportion of these children have cognitive impairment, which has a serious adverse impact on their learning, employment, and social life. This article reviews the latest research on cognitive impairment in children with ALL from the aspects of the influencing factors, detection techniques, and prevention/treatment methods for cognitive impairment.