2021—2022年度系统性红斑狼疮研究进展盘点

Research progress in systemic lupus erythematosus from 2021 to 2022

摘要:

系统性红斑狼疮（systemic lupus erythematosus，SLE）是一种累及多器官系统的自身免疫性疾病，临床表现复杂多样，治疗效果和预后异质性大，给SLE的诊断分型及同质性治疗带来了巨大挑战。以合成生物学、基因组学、蛋白质组学为代表的新技术、新领域的出现，有助于SLE发病机制、生物标志物的深入挖掘，推动了SLE的精准诊疗。该综述总结2021—2022年度SLE最新研究数据和成果，对近2年相关的研究进行回顾及总结。

Abstract:

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organ systems, presenting a complex and diverse clinical manifestation. The heterogeneous treatment response and prognosis of SLE pose significant challenges to its diagnosis, classification, and homogeneous treatment. The emergence of new technologies and fields, such as synthetic biology, genomics, and proteomics, has contributed to a deeper exploration of the pathogenesis and biomarkers of SLE, facilitating precision diagnosis and treatment. This review summarizes the latest research data and achievements in SLE for the years 2021-2022, providing an overview and summary of relevant studies conducted in the past two years.