肺部微生物组与儿童支气管哮喘内型关系的研究进展

Recent research on the relationship between pulmonary microbiome and asthma endotypes in children

摘要:

目前认为支气管哮喘（简称“哮喘”）不是一种单一的疾病，而是一组具有多种表型且机制涉及多条信号通路的综合征。儿童哮喘通常起源于学龄前期，其病因复杂多样。近年来，随着高通量测序技术的发展，发现早期肺部菌群的改变与哮喘的发生发展有关，并且肺部菌群在不同气道炎症（哮喘内型）之间存在显著差异。因此，了解哮喘儿童肺部菌群特点，有助于控制儿童哮喘的进展及改善预后，为哮喘患儿的诊治提供新的思路。

Abstract:

Bronchial asthma is not considered a singular disease, but rather a collection of syndromes with multiple phenotypes and mechanisms that involve various signaling pathways. It typically emerges during the preschool years, and its etiology is intricate and diverse. In recent years, the advancement of high-throughput sequencing technology has revealed that early alterations in lung microbiota may be associated with asthma incidence and progression. Moreover, significant variations in lung microbiota have been observed among different airway inflammation profiles, known as asthma endotypes. Hence, a comprehensive understanding of the characteristics of lung microbiota in children with asthma can aid in managing disease progression and improving long-term prognosis. Additionally, such insights may spark novel approaches to diagnosing and treating childhood asthma.