生长激素激发试验和胰岛素样生长因子1水平检测对生长激素缺乏症的诊断意义和思考

Diagnostic significance and considerations of growth hormone stimulation testing and insulin-like growth factor 1 in growth hormone deficiency

摘要:

生长激素（growth hormone, GH）/胰岛素样生长因子1（insulin growth factor-1, IGF-1）轴是下丘脑/垂体生长激素轴的重要组成部分，对儿童生长发育具有关键性作用。GH/IGF-1轴信号通路及其旁路的紊乱和异常通常在儿童时期表现为身材矮小。身材矮小的儿童通常需进行GH激发试验及IGF-1水平检测，以鉴别生长激素缺乏症（growth hormone deficiency, GHD）和其他导致生长迟缓的原因。该文对GH激发试验和IGF-1检测值进行分析与阐述，以期为临床儿童GHD的诊断提供参考。

Abstract:

The growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis is an essential component of the hypothalamic-pituitary growth hormone axis and plays a crucial role in childhood growth and development. Disruptions and abnormalities in the GH/IGF-1 signaling pathway and its pathways typically manifest as short stature in children. Children with short stature often undergo GH stimulation testing and IGF-1 level measurements to differentiate growth hormone deficiency (GHD) from other causes of growth delay. This article aims to analyze and elucidate the values of GH stimulation testing and IGF-1 measurement, providing reference for the diagnosis of GHD in children.