B细胞激活因子及其靶向药物与炎症性肠病的研究进展

Research advances on B-cell activating factor and its targeted agents in inflammatory bowel disease

摘要:

B细胞激活因子（B-cell activating factor, BAFF）作为B细胞的关键调节因子，参与多种自身免疫性疾病。炎症性肠病（inflammatory bowel disease, IBD）是一组病因尚不明确的慢性、反复发作的肠道炎症性疾病，近年来全球发病率呈上升趋势。多种因素引起的异常免疫反应与IBD发病密切相关，B细胞异常活化及自身抗体产生增加在溃疡性结肠炎的发病中已得到证实，而BAFF是否参与IBD发病机制尚不明确。该文就目前关于BAFF在IBD发病机制中的潜在作用以及在IBD中针对BAFF的靶向治疗研究进行综述，旨在为IBD靶向治疗提供思路。

Abstract:

B-cell activating factor (BAFF), a critical regulator of B cells, is involved in various autoimmune diseases. Inflammatory bowel disease (IBD) is a group of chronic and recurrent intestinal inflammatory disorders with unclear etiology, and its global incidence has been increasing in recent years. Abnormal immune responses triggered by multiple factors are closely related to the pathogenesis of IBD. Previous studies have confirmed the association of B-cell abnormal activation and increased production of autoantibodies with the development of ulcerative colitis. However, the involvement of BAFF in the mechanisms of IBD remains unclear. This review summarizes the potential role of BAFF in the pathogenesis of IBD and provides an overview of targeted therapies on BAFF in IBD, aiming to contribute insights for targeted treatments of IBD.