造血干细胞移植儿童的营养支持进展

Advances in nutritional support for children undergoing hematopoietic stem cell transplantation

摘要:

造血干细胞移植是治疗儿童各种潜在致命的恶性和非恶性疾病的一种选择，如恶性肿瘤、免疫缺陷综合征、严重再生障碍性贫血和遗传代谢性疾病等。移植期间许多因素会影响患儿的营养状况，包括放化疗、胃肠道疾病、移植物抗宿主病及药物等。而营养不良与接受造血干细胞移植患儿的总生存率下降、并发症发生率升高有关，因此移植后营养支持是该类患儿管理的重要组成部分。但是目前国内缺乏关于造血干细胞移植儿童营养支持的指南或共识，因此该文对造血干细胞患儿的营养支持进展进行综述，旨在为临床提供指导。

Abstract:

Hematopoietic stem cell transplantation (HSCT) is a therapeutic option for various potentially life-threatening malignant and non-malignant diseases in children, such as malignancies, immunodeficiency syndromes, severe aplastic anemia, and inherited metabolic disorders. During transplantation, many factors can affect the nutritional status of the children, including radiotherapy, chemotherapy, gastrointestinal disorders, graft-versus-host disease, and medications. Malnutrition has been associated with decreased overall survival and increased complications in children undergoing HSCT, making nutritional support a crucial component of their management. However, currently, there is a lack of guidelines or consensus on nutritional support for children undergoing HSCT in China. Therefore, this review summarizes the progress in nutritional support for children undergoing HSCT, aiming to provide clinical guidance.