肺通气功能正常的儿童支气管哮喘控制情况及急性发作随访的研究
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1.山东第二医科大学临床医学院,山东潍坊 261053;2.山东第一医科大学附属省立医院小儿呼吸科,山东济南 250021

作者简介:

马兰兰,女,硕士,住院医师。

通讯作者:

陈星,女,主任医师。Email: chen_xing9999@163.com。

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Control status and follow-up of acute attacks in children with bronchial asthma with normal pulmonary ventilation function
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2.Department of Pediatric Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China

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    摘要:

    目的 探讨学龄期肺通气功能正常的支气管哮喘(简称“哮喘”)患儿病情控制情况及随访1年内急性发作情况。方法 回顾性分析2021年4—9月327例6~14岁肺通气功能正常哮喘患儿临床资料。根据一秒率实测值,分为≥80%组(267例)和<80%组(60例),比较两组肺通气功能、哮喘控制水平差异,以及随访1年急性发作情况。结果 <80%组基线肺通气功能低于≥80%组,小气道功能障碍比例高于≥80%组(P<0.05);规范治疗1年后,<80%组小气道功能指标均改善,但仍低于≥80%组(P<0.05)。入组时哮喘未完全控制率为34.6%(113/327),<80%组哮喘控制水平低于≥80%组(P<0.05);规范治疗1年后,<80%组哮喘控制水平仍低于≥80%组,且哮喘急性发作比例高于≥80%组(P<0.05)。结论 学龄期哮喘患儿在肺通气功能正常时,仍有约1/3为哮喘未完全控制,其中一秒率实测值低于80%的患儿哮喘急性发作风险增加,需密切随访,强化哮喘管理。

    Abstract:

    Objective To investigate the control status of bronchial asthma (referred to as "asthma") in school-age children with normal pulmonary ventilation function and the occurrence of acute attacks within 1 year of follow-up.Methods A retrospective analysis was conducted on clinical data of 327 children aged 6-14 years with bronchial asthma and normal pulmonary ventilation function from April to September 2021. Based on the measured value of one second rate (FEV1/FVC), the children were divided into the ≥80% group (267 cases) and the <80% group (60 cases). The pulmonary ventilation function, asthma control level, and occurrence of acute attacks within 1 year were compared between the two groups.Results The baseline pulmonary ventilation function in the <80% group was lower than that in the ≥80% group, and the proportion of small airway dysfunction was higher than that in the ≥80% group (P<0.05). After standardized treatment for 1 year, the small airway function indices in the <80% group improved but remained lower than those in the ≥80% group (P<0.05). The rate of incomplete asthma control at baseline was 34.6% (113/327), and the asthma control level in the <80% group was lower than that in the ≥80% group (P<0.05). After standardized treatment for 1 year, the asthma control level in the <80% group remained lower than that in the ≥80% group, and the proportion of acute asthma attacks was higher than that in the ≥80% group (P<0.05).Conclusions Approximately one-third of school-age children with asthma still have incomplete asthma control when their pulmonary ventilation function is normal. Among them, children with measured FEV1/FVC<80% have an increased risk of acute asthma attacks and require close follow-up and strengthened asthma management.

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马兰兰,陈玲,王琴,许阳光,陈星.肺通气功能正常的儿童支气管哮喘控制情况及急性发作随访的研究[J].中国当代儿科杂志,2024,(5):476-480

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  • 收稿日期:2023-11-30
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  • 在线发布日期: 2025-01-15
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