肾小球滤过率评估方法在儿童人群中的应用现状

Current clinical application of glomerular filtration rate assessment methods in pediatric populations

摘要:

肾小球滤过率（glomerular filtration rate, GFR）是重要的肾功能评价指标，而儿童的GFR具有年龄依赖性，在不同疾病状态下可能与成人情况不一致。近年来，学者对GFR的关注度逐渐增加，相关的临床研究日益增多，致力于调整优化GFR的估算，以覆盖儿童整个年龄段。然而，不同疾病状态下，估算GFR的方法和评估方程可能存在差异，从而影响评估的准确性及适用性。该文回顾儿童肾功能的特殊性，探讨GFR的测量方法，并评价不同GFR评估方程在儿童临床实践中的应用情况，为儿童肾功能评估临床实践提供参考。

Abstract:

Glomerular filtration rate (GFR) is a critical indicator of renal function assessment, which exhibits age-dependency in children and may differ from adults under various disease conditions. In recent years, there has been a growing focus on GFR among scholars, with an increasing number of clinical studies dedicated to refining and optimizing GFR estimation to span all pediatric age groups. However, the methods and assessment equations for estimating GFR may vary under different disease conditions, affecting the accuracy and applicability of assessments. This article reviews the peculiarities of renal function in children, explores GFR measurement methods, and evaluates the application of various GFR assessment equations in pediatric clinical practice, providing a reference for clinical assessment of renal function in children.