钙卫蛋白S100 A8/A9对肺炎支原体肺炎患儿病情严重程度的预测价值

Value of calprotectin S100 A8/A9 in predicting the severity of Mycoplasma pneumoniae pneumonia in children

摘要:

目的 探讨钙卫蛋白S100 A8/A9复合物在重症肺炎支原体肺炎（severe Mycoplasma pneumoniae pneumonia, SMPP）患儿病情评估中的作用。方法 前瞻性纳入136例MPP患儿与30例健康对照儿童。根据病情严重程度，将MPP组患儿分为轻症亚组（n=40）和SMPP亚组（n=96）。比较两组及两亚组间S100 A8/A9复合物及相关炎症因子的水平差异，并分析S100 A8/A9在评估MPP严重程度中的作用。结果 MPP组患儿S100 A8/A9显著高于健康对照组，其中SMPP组升高更显著（P<0.05）。多因素logistic回归分析发现血清C反应蛋白（C reactive protein, CRP）及S100 A8/A9升高与SMPP密切相关（P<0.05）。受试者操作特征曲线分析结果显示血清S100 A8/A9联合CRP预测SMPP的曲线下面积为0.904，高于S100 A8/A9、CRP单独预测SMPP的AUC（P<0.05），其特异度为0.718，灵敏度为0.952。结论 S100 A8/A9与MPP病情严重程度密切相关，S100 A8/A9联合CRP更有利于判断MPP患儿的病情严重程度。

Abstract:

Objective To investigate the role of calprotectin S100 A8/A9 complex in evaluating the condition of children with severe Mycoplasma pneumoniae pneumonia (SMPP).Methods A prospective study was conducted among 136 children with Mycoplasma pneumoniae pneumonia (MPP) and 30 healthy controls. According to the severity of the condition, the children with MPP were divided into mild subgroup (40 children) and SMPP subgroup (96 children). The levels of S100 A8/A9 complex and related inflammatory factors were compared between the MPP group and the healthy control group, as well as between the two subgroups of MPP. The role of S100 A8/A9 in assessing the severity of MPP was explored.Results The MPP group had a significantly higher level of S100 A8/A9 than the healthy control group, with a significantly greater increase in the SMPP subgroup (P<0.05). The multivariate logistic regression analysis showed that the increases in serum C reactive protein (CRP) and S100A8/A9 were closely associated with SMPP (P<0.05). The receiver operating characteristic (ROC) curve analysis showed that the combined measurement of serum S100 A8/A9 and CRP had an area under the ROC curve of 0.904 in predicting SMPP, which was significantly higher than the AUC of S100 A8/A9 or CRP alone (P<0.05), with a specificity of 0.718 and a sensitivity of 0.952.Conclusions S100 A8/A9 is closely associated with the severity of MPP, and the combination of S100 A8/A9 with CRP is more advantageous for assessing the severity of MPP in children.