脑电生物反馈联合LSP干预训练在高功能孤独症谱系障碍患儿中的前瞻性随机对照研究

A prospective randomized controlled study of neurofeedback combined with learning style profile intervention training in children with high-functioning autism

摘要:

目的 探讨脑电生物反馈（neurofeedback, NFB）联合学习风格简介（learning style profile, LSP）干预训练在高功能孤独症谱系障碍（high-functioning autism, HFA）患儿中的应用。方法 前瞻性选择2022年2月—2024年2月收治的86例HFA患儿为研究对象，采用随机数字表法分为对照组和观察组，行双盲试验，每组各43例。对照组给予LSP干预训练，观察组在对照组基础上给予NFB干预，两组均干预6个月。比较两组患儿干预前、干预6个月时孤独症行为评定量表（Autism Behavior Checklist, ABC）、孤独症疗效评定量表（Autism Treatment Evaluation Checklist, ATEC）、社交反应量表（Social Responsiveness Scale, SRS）、儿童生存质量量表（Pediatric Quality of Life, PedsQL）评分差异；分析HFA患儿PedsQL评分与ABC、ATEC、SRS评分的相关性。结果 干预6个月后，观察组ABC、ATEC、SRS评分低于对照组，PedsQL评分高于对照组（P<0.05）；HFA患儿PedsQL评分与ABC、ATEC、SRS评分呈负相关（分别r=-0.238、-0.381、-0.219，P<0.001）。结论 NFB联合LSP能够有效改善HFA患儿临床症状及社交能力，控制患儿病情发展，提升患儿生活质量。

Abstract:

Objective To explore the application of neurofeedback (NFB) combined with learning style profile (LSP) intervention training in children with high-functioning autism (HFA).Methods A prospective study was conducted to select 86 children with HFA admitted to the hospital from February 2022 to February 2024. They were divided into two groups according to the random number table method, with 43 cases in each group. In this double-blind study, the control group was given LSP intervention training, and the observation group was given NFB intervention on the basis of the treatment used in the control group. Both groups were treated for 6 months. The scores of Autism Behavior Checklist (ABC), Autism Treatment Evaluation Checklist (ATEC), Social Responsiveness Scale (SRS), and Pediatric Quality of Life (PedsQL) were compared between the two groups before intervention and at 6 months after intervention. The relationship of PedsQL score with ABC, ATEC, and SRS scores was analyzed in children with HFA.Results After 6 months of intervention, the scores of ABC, ATEC, and SRS in the observation group were significantly lower than those in the control group, while the PedsQL score in the observation group was significantly higher than that in the control group (P<0.05). The PedsQL score was negatively correlated with the ABC, ATEC, and SRS scores in children with HFA (r=-0.238, -0.381, -0.219 respectively; P<0.001).Conclusions NFB combined with LSP can effectively improve the clinical symptoms and social ability, control the development of the disease, and improve the quality of life in children with HFA.