新生儿重症监护病房住院早产儿晚发型败血症抗生素使用推荐意见

Recommendations for antibiotic use in hospitalized preterm infants with late-onset sepsis in the neonatal intensive care unit

摘要:

新生儿晚发型败血症（late-onset sepsis, LOS）多见于长期住院的新生儿，尤其是极低出生体重儿（very low birth weight infant, VLBWI）和超低出生体重儿（extremely low birth weight infant, ELBWI）。目前早产儿LOS面临着诊断和治疗不及时以及抗生素过度治疗的双重问题。为此，湖南省新生儿医疗质量控制中心和湖南省医学会围产医学专业委员会新生儿学组组织湖南省新生儿专家根据目前发表的文献和湖南省新生儿医疗质量控制中心统计的数据，并结合湖南省大部分新生儿重症监护病房的实际情况，对新生儿重症监护病房住院早产儿LOS的诊断和抗生素治疗提出了15条推荐意见。

Abstract:

Late-onset sepsis (LOS) is commonly seen in neonates who are hospitalized for extended periods, particularly in very low birth weight infants (VLBWI) and extremely low birth weight infants (ELBWI). Currently, the management of LOS in preterm infants faces dual challenges of delayed diagnosis and treatment, as well as antibiotic overtreatment. To address these issues, the Hunan Neonatal Medical Quality Control Center and the Neonatology Group of Perinatal Medical Committee of Hunan Medical Association organized a group of neonatal experts from Hunan Province to formulate recommendations based on published literature and statistical data from the Hunan Neonatal Medical Quality Control Center, as well as real-world practices in most neonatal intensive care units in Hunan Province. The group of neonatal experts proposed 15 recommendations for the diagnosis and antibiotic treatment of LOS in hospitalized preterm infants in the neonatal intensive care unit.