14例儿童肝母细胞瘤综合治疗的疗效观察

Treatment and outcome of 14 children with hepatoblastoma

摘要:

目的：肝母细胞瘤是儿童时期最为常见的原发性肝脏恶性肿瘤。新辅助化疗﹢手术﹢术后化疗已成为肝母细胞瘤治疗的基本原则。该文旨在总结肝母细胞瘤综合治疗的疗效，进而探讨合理治疗的策略。方法：回顾性分析14例儿童肝母细胞瘤患者的临床资料，并追踪随访其治疗后的生存状况。结果：12例肝母细胞瘤患儿接受全程治疗，中位随访时间为18个月（1.5~74月）。9例无瘤存活，1例死亡，1例肿瘤转移，1例未发现肿瘤残留但术后甲胎蛋白持续不降。结论：手术及规范化疗能有效提高儿童肝母细胞瘤患者的生存率。［中国当代儿科杂志，2009，11（6）：456-459］

Abstract:

OBJECTIVE: To assess the outcome of childhood hepatoblastoma after a combination therapy of resection and chemotherapy. METHODS: The clinical data of 14 children with hepatoblastoma was retrospectively reviewed. Their long-term survival was followed-up. RESULTS: Twelve cases received surgery and planned chemotherapy. The follow-up duration averaged 18 months (range 1.5-74 months). Nine survived free of events, 1 died, 1 survived with multiple lung metastases, and 1 with increased alpha-fetoprotein (AFP) content but without residual tumor. CONCLUSIONS: Surgery assisted with chemotherapy can improve the outcome of hepatoblastoma.［Chin J Contemp Pediatr, 2009, 11 (6):456-459］