Abstract:Objective To observe the relationship between nitric oxide (NO) and glomerulus diseases.Methods The serum nitrite/nitrate (NO 2 -/NO 3 -) ratio was determined through Griess nitrate reduction in 94 children with renal disease as the patient group, including 44 cases of acute nephritis (AN) and 32 cases of nephrotic syndrome (NS) and in addition 28 healthy children as the control group. Results The serum NO 2 -/NO 3 - ratio found in the patient group (AN 70.8±34.7 μmol/L, NS 66.6±27.9 μmol/L, PN 47.4±21.4 μmol/L) were obviously higher than those seen in the control group (30.3±8 μmol/L, (P<0.01) and the ratio was higher in the acute active phase than in the remission phase of glomerulus diseases (P<0.05).Furthermore, NO 2 -/NO 3 - ratio was higher in patients with infection (93.5±32.9 μmol/L) than in the patients without infection (48.7±14 μmol/L, (P<0.01). The serum NO 2 -/NO 3 - ratio in children suffering from nephritic syndrome was negatively correlative with the concentration of the blood cholesterol (P<0.01),while it was correlative with neither plasma albumin level nor the uric protein quantity (P>0.05).Conclusions Nitric oxide seems to be involved in the pathologic process of acute nephritis, nephritic syndrome and purpuric nephritis.
