疑难病研究——原发性骨结外淋巴瘤

A diff icult and compl icated case study :primary extra nodal lymphoma of bo

摘要:

原发性骨结外淋巴瘤是指原发于骨骼部位的淋巴瘤 ,儿童罕见 ,其病因未明。临床表现以局部骨骼病变为主 ,骨关节疼痛和局部骨骼肿胀是最常见的症状 ,伴或不伴有全身症状。放射形态学检查为骨质溶解性病损。病理形态学上存在多样性 ,大部分为大B细胞来源淋巴瘤 (DLBCL)。该病确诊需经骨组织病理活检。治疗采取综合治疗 ,包括化疗与放疗 ,预后相对较好

Abstract:

Primary extra nodal lymphoma of bone means the malignant lymphoma presents initially in bones. It is a rare disease of unknown etiology in children. The disorder mainly manifests in localized bone lesions. Bone arthrodynia and localized bone swelling are the most common symptoms, with or without systemic symptoms. Radiologic examinations reveal osteolytic lesions. The histological features are various, and the majority of histology are diffuse large B cell lymphomas. Diagnosis of the disease may be confirmed by bone biopsy. The prognosis of the patients with this disorder is comparatively favorable after general treatment with chemotherapy and radiation therapy.