败血症患儿血清瘦素水平及其与炎性因子的相关性分析

Levels of serum leptin and their correlations with C-reactive protein, TNF-α and IL-6 in children with septicemia

摘要:

目的 瘦素在抗感染免疫中可能发挥着重要作用 ,该文探讨小儿败血症时血清瘦素水平的变化及其与炎性因子血清C反应蛋白 (CRP)、肿瘤坏死因子 (TNF α)、白细胞介素 6 (IL 6 )的相关性。方法 检测 17例败血症患儿入院后 2 4h内空腹血清瘦素、CRP、TNF α、IL 6的水平 ,并与 15例健康儿童空腹血清瘦素水平比较 ,同时分析患儿血清瘦素水平与CRP、TNF α、IL 6水平的相关性。结果 ①在败血症急性期 ,患儿的血清瘦素水平高于正常对照组 ,差异有显著性 (P <0 .0 1) ;②在败血症患儿中血清瘦素水平与CRP水平显著相关 (r =0 .6 4 7,P <0 .0 1)、与TNF α之间也存在着显著的相关性 (r =0 .5 96 ,P <0 .0 5 ) ,而在瘦素与IL 6之间无相关性 (r =0 .2 5 0 ,P >0 .0 5 )。结论 瘦素作为一种细菌感染的急相反应物可能参与了败血症患儿的抗感染反应。

Abstract:

Objective The hormone leptin is believed to be an important component of the anti-inflammatory cascade. The serum leptin levels were measured as to evaluate whether the levels correlated with C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in children with septicemia. Methods The fasting serum levels of leptin, CRP, TNF-α and IL-6 were measured in 17 children with septicemia and 15 healthy children. Results The serum leptin levels in children with septicemia were significantly higher than those in healthy children (P< 0.01). In the children with septicemia, there were significant correlations between serum leptin levels and CRP levels (r= 0.647, P< 0.01) as well as TNF-α levels (r= 0.596, P< 0.05), while no correlation was found between serum leptin and IL-6 levels (r= 0.250, P> 0.05). Conclusions Leptin could be an acute phase reactant in bacterial infection and could be involved in anti-inflammatory response in children with septicemia.