病毒性心肌炎患儿血清可溶性白细胞介素2受体检测的临床意义

摘要:

目的探讨心肌炎患儿免疫功能的改变。方法应用单克隆抗体夹心酶联免疫吸附试验（ＥＬＩＳＡ）法对３０例病毒性心肌炎急性期患儿可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）进行检测，并与２２例健康儿童对照进行比较。结果病毒性心肌炎患儿血清ｓＩＬ－２Ｒ水平明显升高，为６３２．５６±２９３．４５Ｕ／ｍｌ，在急性期病人中，病程小于１个月者与病程２～６个月者血清ｓＩＬ－２Ｒ无显著性差异。当病毒感染时，机体免疫功能处于紊乱状态，随着病程的延长，病情的迁延不愈，血清ｓＩＬ－２Ｒ一直处于高水平状态。ｓＩＬ－２Ｒ升高可使白细胞介素２（ＩＬ－２）产生受体抑制，从而进一步加重机体的免疫功能紊乱。结论动态观察血清ｓＩＬ－２Ｒ水平对判定病情变化和预后有意义，亦可评估机体的免疫状态。

Abstract:

Objective To study immune function changes in children with myocarditis. Methods ELISA method was used to detect serum soluble interleukin-2 receptor ( sIL-2R ) in 30 children with viral myocarditis and 22 healthy children. Results The serum sIL-2R level in the acute myocarditis group was significantly higher than that of the control group (P<0.01)and the convalescence group (P<0.01). The sIL-2R levels were 632.56±293.45 U/ml ,258.34±135.92 U/ml and 283.17±185.74 U/ml in the group acute, normal, and convalescence respectively. Conclusions The immune function of children with acute viral myocarditis is abnormal. The measurement of serum IL-2R level changes is useful in the evaluation and prognosis of the immune function of patients.