Abstract:Objective To determine the changes of urinary enzymes and the relationship with the peripheral white cell count in po stasphyxial newborns. Methods We divided 28 newborns with asphy xia into 2 groups: mild asphyxia group (10 cases) and severe asphyxia group (18 cases) and 9 normal newborns as controls. The peripheral white cell count, urina ry Nacetyl-β-Dglucosaminidase (NAG), and urinary γglutamy transpeptidase (GGT) were studied within 24 hours of life. Results The peri pheral white cell count and urinary NAG, GGT in the severe asphyxia group were ( 27.42±10.95)×109/L, (34.28±26.18) U/L, (30.50±21.10 ) U/L respectively; those in the mild asphyxia group were (10.24±4.10 )×109/L, (10.34±8.72) U/L, (16.80±6.48) U/L respectively; T hose in the control group were (15.70±3.21)×109/L, (2.73± 2.50) U/L, (8.75±2.43) U/L respectively. The severe asphyxia group wa s higher than those in both the mild asphyxia group and the control group (P<0.05). Except for the peripheral white cell count (P>0.05), NAG and GGT in the mild asphyxia group were higher than those in the control group. The white cell count was positively related to the levels of urinary NAG (r=0.41,P<0.05) and GGT (r=0.22,P>0.05) in the severe as phyxia group. Conclusions The peripheral increased white cell c ount was related to the severity of asphyxia and changes of urinary enzymes, whi ch may be a predicting parameter for postasphyxial renal damage.
