Abstract:OBJECTIVE: The degree of renal tubulointerstitial injury determines the prognosis of renal disease. This research studied the relationship among mononuclear cells infiltration, the degree of renal tubulointerstitial injury and the prognosis of renal disease, so as to explore the effect of mononuclear cells infiltration in prognosis of renal disease. METHODS: The renal biopsy specimens from 42 children with primary or secondary kidney disease were studied. Mononuclear cells were detected by CD4+, CD8+ or CD68+ immunohistochemistry. The relationship among the expressions of CD4+, CD8+ and CD68+ in the renal interstitium, renal tubulointerstitial pathological changes and prognosis of renal diseases were analyzed. RESULTS: There were positive correlations between the expressions of CD4+, CD8+ and CD68+ in the renal interstitium and renal tubulointerstitial pathological changes (r_s=0.570,P=0.029;r_s=0.368,P=0.009, r_s=0.468, P=0.003). The renal tubulointerstitial pathological changes were also positively correlated to the prognosis of renal diseases (r_s=0.467, P= 0.001). The expressions of CD8+ and CD68+ in renal interstitium and the prognosis of kidney diseases were correlated (r_s=0.398,P=0.004;r_s=0.328,P=0.036). CONCLUSIONS: There is a close relationship between the density and varieties of infiltrated mononuclear cells in renal interstitium and the prognosis of renal diseases. The mononuclear cells filtration may induce the renal tubulointerstitial fibrosis and result in a poor prognosis of kidney diseases.
