Temporal expression of thyroid transcription factor-1 in fetal and neonatal human lungs
DOI:
CSTR:
Author:
Affiliation:

Clc Number:

R722

Fund Project:

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    OBJECTIVE: Recent progress in developmental biology has shown that the thyroid transcription factor-1 (TTF-1) plays an important role in lung development. The aim of this study was to investigate the expression and distribution of TTF-1 and its function during the development of epithelial stem cells in fetal human lungs. METHODS: Human lung tissues were obtained with parental consent from 32 fetuses (10-27 weeks) and from seven newborn infants (28-36 weeks) who had not died from pulmonary diseases. The expression of TTF-1 was examined by immunohistochemistry. RESULTS: TTF-1 was expressed in the nuclei of columnar nonciliated epithelial cells of the fetal human lung as early as 10 weeks of gestation. With the development of bronchus TTF-1 positive cells were present in scattered nonciliated cells and were predominantly expressed in the nuclei of epithelial cells of the distal tubules and lung buds. By the late phase of fetal development or neonatal period, TTF-1 was expressed in only type Ⅱ alveolar epithelium cells and their precursor cells,but was absent in ciliated cells and type Ⅰ alveolar epithelium cells. CONCLUSIONS: TTF-1 can stimulate the growth of both bronchial trees and alveolar cells and regulate the type Ⅱ alveolar epithelium cells and their precursors to secret surfactants.

    Reference
    Related
    Cited by
Get Citation

孔祥永, 杜江, 封志纯.甲状腺转录因子-1在人胎肺和新生儿肺上皮细胞中的时序表达[J].中国当代儿科杂志英文版,2006,8(1):30-32

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:
  • Revised:
  • Adopted:
  • Online: January 25,2006
  • Published:
Article QR Code