Changes of high-sensitivity CRP and insulin sensitivity index in children with obstructive sleep apnea hypopnea syndrome

Abstract:

OBJECTIVE: To investigate the levels of highsensitivity CRP (hsCRP) and insulin sensitivity index (ISI) in children with obstructive sleep apnea hypopnea syndrome (OSAHS). METHODS: Twenty-nine children with OSAHS and 22 children with primary snoring (PS) were enrolled. Polysomnography was performed. Body mass index (BMI), hsCRP, serum lipids, fasting plasma glucose (FPG), and insulin (INS) were measured. ISI was calculated. RESULTS: The apnea hypopnea index (AHI) in the OSAHS group was higher than that in the PS group (13.2±9.2 vs 1.2±1.1; P<0.05). The lowest oxygen saturation (LSaO2) in the OSAHS group was lower than that in the PS group ［(78.5±5.4)% vs (87.4±3.7)%; P<0.05］. The values of hsCRP in the OSAHS group was higher than those in the PS group (2.8±2.7 mg/L vs 0.6±0.9 mg/L; P<0.05). There were no significant differences in the ISI and serum lipids between the two groups. The hsCRP level was negatively correlated with LSaO2 in the OSAHS group (r=-0.531, P<0.05). CONCLUSIONS: The hsCRP level increases in children with OSAHS. The increased hsCRP level might be associated with an increased risk of cardiovascular diseases.