Clinical significance of anti-D IgG screening and titer detection in 286 RhD negative pregnant women
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R722.18

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    Abstract:

    OBJECTIVE: Anti-D IgG in RhD negative pregnant women is the main antibody of Rh-induced hemolytic disease of newborn (HDN). The study aimed to investigate the clinical significance of anti-D IgG screening and titer detection in RhD negative pregnant women. METHODS: Sera of 286 RhD negative pregnant women were collected. Microtube column indirect antiglobulin test was used to screen and identify anti-D IgG. The indirect antiglobulin test was used to test the titer of anti-D IgG. RESULTS: Anti-D IgG was identified in 21 cases (7.3%). The titer of anti-D showed an increasing trend with pregnancy progresses. The clinical outcomes of 12 fetuses (newborns) from positive anti-D pregnant women were observed. Two cases died in utero, 2 cases did not show abnormality and 8 cases had hemolysis. The 8 cases with hemolysis were treated with exchange transfusion or blood transfusion, and they had a good prognosis. CONCLUSIONS: The screening and titer detection of anti-D IgG in RhD negative pregnant women are valuable in the prediction and treatment of HDN.[Chin J Contemp Pediatr, 2009, 11 (3):185-187]

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刘开良, 李宁, 李碧娟, 彭金艳, 舒象武, 禹云英.286例RhD阴性孕妇血清IgG抗-D筛查与效价检测的意义[J].中国当代儿科杂志英文版,2009,11(03):185-187

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  • Received:
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  • Online: March 15,2009
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