Abstract:Objective To study the changes of nitric oxide (NO) and endothelin-1 (ET-1) and the relationship between these changes and this prognosis in newborns with pulmonary hemorrhage (PH). Methods Nitric acid reductase and radioimmunoassay methods were respectively used to measure concentrations of serum NO and plasma ET-1 in group control (n=15), group survival with PH within an acute phase (survival, n=13), group survival with PH within a recovery phase (recovery, n=13) and group deadth with PH (deadth, n=7). Results The concentrations of serum NO were 63.0±10.7 μmol/L, 32.0±7.5 μmol/L, 68.2±6.9μmol/L and 20.1±5.2 μmol/L in group control, group survival, group recovery and group death respectively. The concentrations of ET-1 were 19.6 ± 4.0 ng/L, 43.0 ± 8.9 ng/L, 20.7 ± 4.5 ng/L and 54.1±3.9 ng/L respectively. The rates of NO/ET-1 were 3.21, 0.74, 3.29 and 0.37 respectively. The differences among the four groups were markedly significant.Conclusions The concentration of NO is decreased, while the concentration of ET-1 is elevated in newborns with PH.The rate of NO/ET-1 is strongly correlated with the severity of illness and may be considered as an indicator of the prognosis of PH.
