Diagnostic value of specific antiheart autoantibodies in children with cardiomyopathy

Abstract:

Objective To explore the diagnostic value of specific antiheart autoantibodies in children with myocardiac disease. Methods The plasma autoantibody against myocardiac adenine nucleotide translocator (ANT) and anti-myosin in children with myocardiac diseases, 30 cases with viral myocarditis (VMC) and 14 cases with dilated cardiomyopathy (DCM), were detected by western blot and enzyme-linked immunosorben assay. Results The plasma levels of anti-ANT and anti-myosin in the VMC and DCM group were significantly higher than those in the healthy group (P<0.05). The diagnostic sensitivity and specifity of anti-ANT and anti-myosin for VMC and DCM were 72.73%, 100% and 54.55%, 96%.Conclusions The anti-ANT and anti-myosin can be taken as specific markers of diagnosis for VMC and DCM . They have important value for differential diagnosis in children with cardiomyopathy, and can be extended to primary hospitals.