Quantitative analysis of myelin basic protein in serum and cerebrospinal fluid in children with central nervous system diseases

Abstract:

Objective To investigate the change of myelin basic protein (MBP) in serum and CSF in children with central nervous system (CNS) diseases and its clinic significance, and to find a biochemistry index for CNS damage.Methods The ELISA method was used to determine the level of MBP in the serum and CSF of 85 cases of CNS diseases (58 males and 27 females, 1m～13y in age), including CNS infection, convalescence of HIE, delayed Vitmine K deficiency-induced intracranial hemorrhage, febrile convulsion and CNS tumor.Results Both means of MBP in serum and CSF were apparently higher in the CNS diseases group those of the control group. Conclusions There are different degree increase of MBP in serum and CSF in different CNS diseases, indicating a demyelinating pathological course and injurg of blood-brain barrier. The level of MBP in serum and CSF may taken as a biochemical index of reflecting CNS injury.