An animal model of subthreshold convulsant discharges by giving subconvulant electrical stimulus

Abstract:

Objective To set up an animal model of subthreshold convulsant discharges (SCD) and to study the effects of SCD on learning and memory ability of space changes in rats.Methods Chronic electrodes were placed in the anterior frontal cortex of 18 male Wistar rats. Under continuous ECoG recording, electrial stimulation was given to the anterior frontal cortex of the rats. Changes of behaviors and ECoG of the rats were observed simultaneously. Results Epileptiform EEG discharges in the cortex and hippocampus were induced without seizure during the subconvulant electric stimulation (SES) to the anterior frontal cortex. Conclusions The anterior frontal cortex SES can cause SCD in the cortex and hippocampus.