Abstract:Objective To study the effect of Lovastatin on experimental glomerular injury. Methods After nephritic syndrome model was induced with adriamycin, 16 male Wistar rats were fed with high lipid diet and divided randomly into the control group and treatment group. A dose of 4 mg/kg of Lovastatin was given daily only in the treatment group. The 24-hour urinary protein was measured every two weeks, and the serum lipid and protein were determined every four weeks. After 12 weeks, renal tissues were examined by light microscopy. Results The level of pathomorphologic score and percentage of glomerules with foam cell were 1.81±0.11 and 43.21±4.89% respectively in the control group, and 0.91±0.17 and 21.09±3.31% in the treatment group.Both pathomorphologic score and percentage of glomerules with foam cells were significantly lower in the treatment group than in the control group (P<0.01). The values of the 24-hour urinary protein excretion in the treatment group (10 weeks: 208.9±60.4 g/L; 12 weeks: 160.5±48.6 g/L) were lower than those seen in the control group (10 weeks: 276.1±57.3 g/L ; 12 weeks: 262.4±72.7 g/L) (P<0.05 and P<0.01) after ten weeks. Conclusions Lovastatin seems to significantly alleviate lipidemia, to ameliorate hyperlipidemia-induced glomerrular injury and to decrease urinary protein excretion.
