Effects of prepulside on neonatal hyperbilirubnemia

Abstract:

Objective To evaluate the effects of prepuside on hyperbilirubinemia in newborns. Methods 89 neonatal infants with hyperbilirubinemia were divided randomly into the conventional and prepulside therapy groups. All the patients were administrated the same conventional treatment and only the patients in the prepulside group received prepulside at a dose of 0.2 mg/kg, 3 times per day for 7 days. Serum bilirubin levels were determined before and on the 7 th day after the start of treatment.Results Bilirubin levels decreased by an average of 53.18±22.36 μmol/L per day in the prepulside group and of 35.86±22.36 μmol/L per day in the conventional group (P<0.01).Conclusions Prepulside as a supplementary therapy in the treatment of neonatal hyperbilirubinemia promotes the decrease of serum bilirubin levels and shortens the course of treatment.