Research progress on the relationship between SLCO1B1 gene and neonatal jaundice

Abstract:

Organic anion transporter 2 (OATP2) is an uptake transporter located on the basolateral membrane of human hepatocytes. It mediates the transportation of various organic solutes including bilirubin and impacts bilirubinm etabolism. It is encoded by the gene of solute carrier organic anion transporter family member 1B1 and the genevariants that inhibit hepatic bilirubin uptake function may reduce the normal functional level of bilirubin eliminationand result in neonatal hyperbilirubinemia. In recent years, some studies have indicated that variants of SLCO1B1 areassociated with neonatal jaundice. This article reviews the research advance in SLCO1B1 with respect to the structureand function and the relationship between SLCO1B1 mutations and neonatal jaundice.