Research progress on the relationship between SLCO1B1 gene and neonatal jaundice
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    Abstract:

    Organic anion transporter 2 (OATP2) is an uptake transporter located on the basolateral membrane of human hepatocytes. It mediates the transportation of various organic solutes including bilirubin and impacts bilirubinm etabolism. It is encoded by the gene of solute carrier organic anion transporter family member 1B1 and the genevariants that inhibit hepatic bilirubin uptake function may reduce the normal functional level of bilirubin eliminationand result in neonatal hyperbilirubinemia. In recent years, some studies have indicated that variants of SLCO1B1 areassociated with neonatal jaundice. This article reviews the research advance in SLCO1B1 with respect to the structureand function and the relationship between SLCO1B1 mutations and neonatal jaundice.

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陆岸锋, 钟丹妮.有机阴离子转运体1B1基因与新生儿黄疸关系的研究进展[J].中国当代儿科杂志英文版,2014,16(11):1183-1187

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History
  • Received:April 16,2014
  • Revised:June 19,2014
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  • Online: November 15,2014
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