Expression of TGF-β1 and PAI-1 in premature infants with bronchopulmonary dysplasia
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    Abstract:

    Objective To study the expression of transforming growth factor-β1 (TGF-β1) and plasminogen activator inhibitor-1 (PAI-1) and its significance in premature infants with bronchopulmonary dysplasia (BPD). Methods A retrospective analysis was performed on the clinical data of 96 very low birth weight infants (gestational age of ≤32 weeks) who survived for more than 28 days and were admitted to the Neonatal Intensive Care Unit between January 2010 and December 2012. These subjects were divided into BPD group (n=21) and non-BPD group (n=75). The expression of TGF-β1 and PAI-1 in blood was measured by ELISA. Results The levels of TGF-β1 and PAI- 1 in the BPD group increased gradually from the 7th day to the 14th day and then to the 21st day after birth, and were significantly higher than in the non-BPD group at all time points (P<0.01). The TGF-β1 and PAI-1 levels in the non-BPD group on the 7th, 14th, and 21st days after birth were not significantly different from each other (P>0.05). Conclusions The expression of TGF-β1 and PAI-1 in blood is elevated in premature infants with BPD, which may be associated with the development of BPD.

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张金凤, 黄润忠, 黄冠芬, 欧伟明, 李剑峰, 陈锦金. TGF-β1 和PAI-1 在早产儿支气管肺发育不良中的表达及意义[J].中国当代儿科杂志英文版,2014,16(8):810-813

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History
  • Received:January 17,2014
  • Revised:April 21,2014
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  • Online: August 15,2014
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