Relationship between serum uric acid level and metabolic syndrome in Uygur children and adolescents with overweight or obesity

Abstract:

Objective To study the relationship between serum uric acid（SUA) level and metabolic syndrome（MS) in Uygur children and adolescents with overweight or obesity.Methods A total of 173 Uygur children or adolescents who were either overweight or obese and 200 controls with normal body weight were included in the study. Body weight, height, waist circumference, fasting blood glucose, total cholesterol, high-density lipoprotein cholesterol, lowdensity lipoprotein cholesterol, triglycerides, and SUA were measured. Results The overweight and obesity groups had significantly higher SUA levels（235±42 and 285±42 μmol/L respectively) than the control group（199±32 μmol/L; P<0.01). The subjects with SUA levels of 300-349 μmol/L and ≥350 μmol/L had significantly higher incidence of MS, overweight/obesity, hypertension and dyslipidemia than those with SUA levels of <250 μmol/L and 250-299 μmol/L（P<0.01). There were significant differences in SUA levels between groups with different MS components. SUA level was significantly increased in groups with more MS components（P<0.01). Every 1 kg/m² increment in body mass index（BMI) was associated with 5.74 μmol/L increase in SUA level, according to a multivariate regression analysis.Conclusion Uygur children and adolescents who are either overweight or obese have higher SUA levels than those with normal body weight. The incidence of MS and its components rises with increasing SUA level. BMI has a positive relationship with SUA.