Association between CYP1A1*2A polymorphism and susceptibility to childhood acute lymphoblastic leukemia:a Meta analysis

Abstract:

Objective To explore the association between CYP1A1^*2A polymorphism and susceptibility to childhood acute lymphoblastic leukemia (ALL) through a Meta analysis. Methods Inclusion and exclusion criteria were formulated and English and Chinese databases (PubMed, OVID Database, CBM, CNKI, and Wanfang Data) were searched comprehensively. The studies (from January 1999 to April 2015) related to the association between CYP1A1^*2A polymorphism and susceptibility to childhood ALL were collected. STATA 12.0 Software was applied to perform the Meta analysis for the articles included. Results A total of 12 articles were included for analysis (11 English articles and 1 Chinese article), which involved 3 355 cases in total. The results of the Meta analysis showed a significant association between CYP1A1^*2A polymorphism and susceptibility to childhood ALL (allele model:OR=1.31, 95%CI:1.07-1.61;dominant model:OR=1.33, 95%CI:1.13-1.56;codominant model:OR=1.30, 95%CI:1.10-1.54). According to the results of a subgroup analysis based on ethnic origin, an increased risk of childhood ALL was observed in both Asian subgroup (dominant model:OR=1.57, 95%CI:1.19-2.08;codominant model:OR=1.61, 95%CI:1.20-2.17) and the Caucasian subgroup (allele model:OR=1.31, 95%CI:1.04-1.63;dominant model:OR=1.22, 95%CI:1.00-1.49). Conclusions CYP1A1^*2A polymorphism may be associated with the genetic susceptibility to childhood ALL.