Association between tumor necrosis factor-α G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth

Abstract:

Objective To study the association between tumor necrosis factor-α (TNF-α) G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth (SPTB). Methods The case group enrolled 753 SPTB infants and the control group included 681 term infants. TNF-α G-308A polymorphisms were genotyped using Sequenom MassARRAY^® SNP. Results The frequencies of the allele (G and A) in the case and control groups were not significantly different (P=0.35). The frequencies of the genotypes (GG, GA and AA) in the case and control groups were not significantly different (P=0.64). The logistic regression analysis found that TNF-α G-308A was not associated with genetic susceptibility to SPTB (OR=0.85; 95%CI:0.61-1.19;P=0.35). Conclusions There is no association between the polymorphisms of TNF-α G-308A and the genetic susceptibility to SPTB.