Change in serum follistatin-like protein 1 and its clinical significance in children with chronic heart failure

Abstract:

Objective To investigate the change in the serum level of follistatin-like protein 1(FSTL1) in children with chronic heart failure and its correlation with left ventricular remodeling.Methods A total of 45 children with chronic heart failure(CHF) between May 2014 and May 2015 were selected as the CHF group, among whom 21 had endocardial fibroelastosis(EFE) and 24 had dilated cardiomyopathy(DCM);another 30 healthy children were selected as the control group.Enzyme-linked immunosorbent assay was applied to measure the serum level of FSTL1.Radioimmunoassay was applied to measure N-terminal pro-brain natriuretic peptide, and echocardiography was applied to measure the indicators of left ventricular remodeling.The correlation between the serum level of FSTL1 and left ventricular remodeling was analyzed by Pearson correlation and Spearman's rank correlation analysis.Results Before treatment, the CHF group had a significantly higher serum level of FSTL1 than the control group(P<0.05), which gradually increased with aggravation of CHF(P<0.05).The serum level of FSTL1 showed no significant difference between the EFE and DCM groups(P=0.176).Serum level of FSTL1 was positively correlated with left ventricular enddiastolic diameter(r=0.485, P=0.001), left ventricular mass(r=0.322, P=0.031), left ventricular mass index(r=0.353, P=0.017), and N-terminal pro-brain natriuretic peptide(r=0.562 P<0.001), and was negatively correlated with left ventricular ejection fraction(r=-0.436, P=0.003) and left ventricular minor axis decurtation rate(r=-0.436, P=0.003).Conclusions FSTL1 might take part in the left ventricular remodeling in children with CHF, and the serum level of FSTL1 can be used as an objective index for clinical diagnosis and severity assessment of CHF in children.