Changes in blood oxygen metabolism indices and their clinical signifcance in children with septic shock

Abstract:

The key to the treatment of septic shock is to provide adequate oxygen supply and improve tissue perfusion. Lactate and central venous oxygen saturation (ScvO₂) are commonly used as the indices of oxygen metabolism, but tissue hypoxia may still exist even when lactate and ScvO₂ are within the normal range. Arteriovenous difference in carbon dioxide partial pressure (CO₂ gap) can accurately reflect oxygen delivery when ScvO₂ is in the normal range. This article reviews the advantages and shortages of lactate, lactate clearance rate, ScvO₂, and CO₂ gap in evaluating tissue hypoxia, in order to provide a reference for treatment and severity evaluation of septic shock.