Risk factors for poor prognosis in children with severe adenovirus pneumonia

Abstract:

Objective To investigate the risk factors for poor prognosis of severe adenovirus pneumonia (SAP) in children. Methods The clinical data of 189 children with SAP were retrospectively analyzed. Univariate logistic regression analysis was performed to assess the risk factors for poor prognosis. Results The univariate logistic regression analysis showed that the patients with hemoglobin < 90 g/L, plasma albumin < 30 g/L, C-reactive protein > 30 mg/L, procalcitonin > 10 ng/mL, alanine aminotransferase > 100 U/L, or aspartate aminotransferase > 100 U/L had poor prognosis (P < 0.05), and that those with congenital dysplasia of the airway, acute respiratory distress syndrome, circulatory complications, electrolyte and acid-base disturbance, or more than three complications also had poor prognosis (P < 0.05). Conclusions Poor prognosis of severe adenovirus pneumonia in children is associated with anemia, low serum albumin, inflammatory response, concurrent multiple complications and underlying lung diseases.