Application of humidified high-flow nasal cannula in neonates with meconium aspiration syndrome and pulmonary hypertension after extubation
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    Abstract:

    Objective To investigate the clinical value of humidified high-flow nasal cannula (HHFNC) as a respiratory support after extubation by comparing it with nasal continuous positive airway pressure (NCPAP) in neonates with meconium aspiration syndrome (MAS) and persistent pulmonary hypertension of the newborn (PPHN). Methods A total of 78 neonates with MAS and PPHN were randomly administered with HHFNC or NCPAP immediately after extubation. The following indices were compared between the two groups:blood gas parameters, duration of noninvasive ventilation, rate of extubation failure, and incidence of complications, such as nasal damage, abdominal distension, and intraventricular hemorrhage. Results There were no significant differences in the rate of extubation failure, PaO2, PCO2, and PaO2/FiO2 ratio at one hour after NCPAP or HHFNC, duration of noninvasive ventilation, time to full enteral feeding, length of hospital stay, and incidence of intraventricular hemorrhage between the two groups (P > 0.05). The HHFNC group had significantly lower incidence of nasal damage (5.0% vs 31.6%; P < 0.05) and incidence of abdominal distension (7.5% vs 34.2%; P < 0.05) than the NCPAP group. Conclusions Both NCPAP and HHFNC can be used as the sequential therapy for neonates with MSA and PPHN after extubation, and they both have a definite effect. As a new strategy of respiratory support, HHFNC is better tolerated, and has fewer side effects than NCPAP.

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高晓燕, 冯琳, 邱玉芬, 潘新年.加温湿化高流量鼻导管通气在胎粪吸入综合征并肺动脉高压机械通气撤机中的应用研究[J].中国当代儿科杂志英文版,2017,19(4):393-397

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  • Received:September 22,2016
  • Revised:November 27,2016
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