Advances in targeted therapy for childhood acute myeloid leukemia

Abstract:

At present, acute myeloid leukemia (AML) accounts for about 15%-20% of childhood acute leukemia. Although overall survival rate is increasing with the help of risk stratification, stratification of chemotherapy, and supportive treatment, conventional pharmacotherapy still has a limited clinical effect and certain limitations in improving remission rate in previously untreated patients and reducing recurrence after remission. With the development of precision medicine, the mechanisms of targeted therapy, including abnormal activation of AML-related signaling pathways and epigenetic modifcation, have been found in recent years. Molecular-targeted drugs can therefore act on specifc receptors and target genes to improve clinical effect and the prognosis of AML patients.