Effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children: a Meta analysis
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    Abstract:

    Objective To systematically review the effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children. Methods RevMan5.3 was used to perform a Meta analysis of randomized controlled trials on the effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children published between January 2008 and May 2018 across the world. A subgroup analysis was conducted according to the type of probiotics for intervention, follow-up time, time of probiotic supplementation, and study areas. Results A total of 22 articles were selected, with 3 280 cases in the intervention group and 3 281 cases in the control group. The results of pooled effect size showed that probiotic supplementation during pregnancy and/or infancy significantly reduced the incidence rate of atopic dermatitis (RR=0.81, 95% CI:0.70-0.93, P < 0.05). According to the subgroup analysis, the intervention with Lactobacillus and Bifidobacterium had a significant effect (RR=0.68, 95% CI:0.52-0.90, P < 0.05); probiotic supplementation during both pregnancy and infancy also had a significant effect (RR=0.77, 95% CI:0.66-0.90, P < 0.05); probiotic supplementation during pregnancy and/or infancy had a better effect in preventing atopic dermatitis in children aged ≤ 2 years than in those aged > 2 years (RR=0.74, 95% CI:0.61-0.90, P < 0.05); probiotic supplementation had a significant effect in Australia (RR=0.83, 95% CI:0.73-0.96, P < 0.05) and Europe/the United States (RR=0.74, 95% CI:0.61-0.91, P < 0.05). Heterogeneity was mainly due to follow-up time (I2=62.7%) and time of probiotic supplementation (I2=53.5%). Conclusions Probiotic supplementation during pregnancy and infancy helps to prevent atopic dermatitis in children, and mixed Lactobacillus-Bifidobacterium intervention has a better effect.

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殷道根, 何珍, 段学燕, 范飞翔, 廖小兵, 王庆川.孕期及婴幼儿期补充益生菌预防儿童特应性皮炎效果的Meta分析[J].中国当代儿科杂志英文版,2019,21(1):82-88

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  • Received:August 08,2018
  • Revised:November 01,2018
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  • Online: January 25,2019
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