Association between maternal alcohol consumption and risk of congenital heart disease in offspring: a Meta analysis

Abstract:

Objective To study the association between maternal alcohol consumption and the risk of congenital heart disease (CHD) in offspring. Methods PubMed, Cochrane Library, Web of Science, Google Scholar, China Biology Medicine disc, Wanfang Database, CNKI Database, and Weipu Database were searched for the articles on the association between maternal alcohol consumption and congenital heart disease in offspring. These articles were published up to November 30, 2019. A random effects model or a fixed effects model was used for the pooled analysis of the results of each study, and then the pooled effective value and its 95%CI were calculated. A subgroup analysis was performed to explore heterogeneous regulators. Funnel plots and an Egger's test were used to assess publication bias. Results A total of 4 409 articles were searched, and 55 articles were finally included in this analysis, among which there were 6 cohort studies and 49 case-control studies. The Meta analysis showed heterogeneity across all studies (I²=74%, P < 0.01). The random effects model showed that maternal alcohol consumption was associated with CHD in offspring, with an OR of 1.18 (95%CI:1.09-1.28). The Egger's test showed a certain degree of publication bias (P < 0.05), and after adjustment, the pooled OR of CHD in offspring was 1.10 (95%CI:1.01-1.21). Conclusions Maternal alcohol consumption may increase the risk of CHD in offspring.