A review on the genetic mechanism of chromatin remodeling in children with neurodevelopmental disorders

Abstract:

Neural development is regulated by both external environment and internal signals,and in addition to transcription factors,epigenetic modifications also play an important role.By focusing on the genetic mechanism of ATP-dependent chromatin remodeling in children with neurodevelopmental disorders,this article elaborates on the effect of four chromatin remodeling complexes on neurogenesis and the development and maturation of neurons and neuroglial cells and introduces the clinical research advances in neurodevelopmental disorders.