Antimicrobial resistance of 36 strains of Helicobacter pylori in adolescents

Abstract:

OBJECTIVE: To investigate the resistance of Helicobacter pylori (H.pylori) to antimicrobial agents in adolescents. METHODS: One hundred and eight adolescents (6-18 years old) underwent a gastroscopy examination. H.pylori strains were isolated from gastric mucosa. Antimicrobial susceptibility testing was performed by means of Kirby-Baner. RESULTS: Thirty-six H.pylori strains were identified. The resistant rate of H.pylori strains to clarithromycin, fruranzolidone and amoxicillin was 8.3%, 16.7% and 33.3%, respectively. H.pylori strains showed a high resistance to metronidazole (94.4%), while no strain was resistant to gentamicin and levofloxacin. CONCLUSIONS:The H.pylori strains from the adolescents in Zhejiang showed a high resistance to metronidazole and amoxicillin but a low resistance to clarithromycin and fruranzolidone. All of H.pylori strains were susceptive to gentamicin and levofloxacin.［Chin J Contemp Pediatr, 2009, 11 (3):210-212］