Abstract:OBJECTIVE: PPAR-γ is associated with the differentiation, apoptosis, proliferation and cytokine secretion of immunologic cells. This study investigated peripheral blood lymphoblastic PPAR-γ mRNA expression and its correlation with plasma IL-13 contents in children with acute idiopathic thrombocytopenic purpura (ITP). METHODS: Fifty-three children with acute ITP who were in line with the standard test between September 2007 and July 2008 were enrolled. Fifty healthy children during the same period were used as the control group. PPAR-γ mRNA expression in peripheral blood lymphocytes were detected by RT-PCR. Plasma IL-13 contents were detected using ELISA. RESULTS: PPAR-γ mRNA expression in peripheral blood lymphocytes from acute ITP children were significantly higher than that in the control group (0.78 ± 0.03 vs 0.52 ± 0.05; P<0.05). Plasma IL-13 contents in children with acute ITP were also significantly higher than those in the control group (160.21 ± 34.26 pg / mL vs 121.42 ± 12.69 pg / mL; P<0.05). There was a positive correlation between plasma IL-13 level and lymphoblastic PPAR-γmRNA expression in children with ITP (r=0.89, P<0.05). CONCLUSIONS: PPAR-γ mRNA expression in peripheral blood lymphocytes increased and were positively correlated with plasma IL-13 contents in children with acute ITP, suggesting that PPAR-γ and IL-13 might participate in the pathogenesis of acute ITP.［Chin J Contemp Pediatr, 2009, 11 (5):367-370］
